I have been sick for two years with lymes/ mold exposure, and started having allergic reactions on and off two yrs ago around my periods. I am getting familiar with methylation and took genetic test and have one MTHFR gene mutation and both COMT ++ genes. I started having anaphylaxis reactions in last two months around my periods, I am recognizing this as histamine/ progesterone issues. I am gf, dairy free, organic, low histamine diet. I started B- minus through ben lynch, and hydroxy B12 as I don't process frolic acid. I am also on vit D3 coq10, I am wondering if my reactions could be due to high doses of b12 and not methyl groups or if my histamine bucket just got to full or both? I see a ton of different approaches to methylation and honestly they all freak me out and they all seem to be confusing, can someone direct me or help me? I am scared to have another reaction?