While it's true that Genetic SNP's mutations might not mean much by themselves, but I have come across a lot of conflicting info about the A1298C mutation & the need for Methyl Folate? I am homozygous A1298C & I don't do well with MTHF beyond a certain point (800 mcg/ day) or for that matter any of the "methyl" rich supplements like P5P. I have also heard & read about the need for biopterin with this mutation. I have never supplemented it but I have tried to increase it naturally. I am not sure how effective is the strategy to increase it naturally. What has your experience been with Methylation supplements if you have A1298C mutation?