Hi Rich,
Thank you for the detailed explanation of histamine reactions and the scapegoat nature of blaming adrenals for body malfunctions. I am trying to utilize this information, along with my own anecdotal records, in moving forward with the methylation protocol. Since starting the protocol about 3 months ago, my histamine reactions and sulfite sensitivity have gotten much worse..........so...........based on your explanation of histamine which cofactor might be a next step? It may also be helpful to know that my lab tests do show low B6, and I have compound heterozygous MTHFR gene mutations (1298 and 677). I currently take 500 mcg Mb12, 2 mg adb12, 400 mcg Solgar Metafolin. I haven't found a b complex that I can tolerate yet (I did try Pure Encapsulation a couple of months ago...might give it another go now that excitotoxicty has calmed). I take separate B6, B5, B2, Biotin, Vit C, D3, E, A, magnesium, calcium, zinc, and molybdenum for sulfite issues after increasing folate. I would love to hear from Freddd and you both on next steps.
Hi, therron.
Molybdenum is the best I know of for sulfite sensitivity. Some have taken dosages up to 500 micrograms per day. If this doesn't correct the sulfite symptoms, then you may have upregulating SNPs in your CBS enzyme. You could consider Dr. Amy Yasko's socalled "ammonia program" for helping this. She describes it in her book Autism, Pathways to Recovery. I should note that I do not agree with lowering protein intake, which is one of her recommendations on this program. That hasn't turned out to be a good idea in ME/CFS, though it may be O.K. in autism.
For histamine, folinic acid, copper and B6 (together with B2) are the best measures I know of. The histamine situation should improve as the methylation cycle and the folate metabolism recover. Copper should not be overdone, and it's a good idea to take zinc with it, at a dosage of about 10 to 15 times as high as the copper. Too much copper can promote oxidative stress, but it is essential to have enough of it. I favor doing lab testing to see what the status of the minerals is. As always, I encourage you to be working with a physician.
Best regards,
Rich