Can somebody (Rich?) explain methylation to me in simple terms? I've read Rich's simplified methylation block protocol, and it's straightforward enough, but what IS a methylation block? My sister developed symptoms similar to ME/CFS following chemotherapy for cancer. It started with peripheral neuropathy and has slowly progressed. She recently had a tilt-table test and tested positive for orthostatic hypotension, but her doctor doesn't seem to know much about it. She's sleeping 12 hours a day and is very fatigued, has brain fog, pain, etc. It sounds very similar to my ME/CFS. I mentioned methylation block to her, but I couldn't explain it because I don't understand it myself. Can someone explain the concept in a way that I can understand through the brain fog, and maybe give me some links about it that I could pass along? Thanks.