I’m stumped. I tried to figure this out on my own by researching the forum and by trial-and-error’ing new things, but I humbly ask for some experts’ help. I can’t seem to get a handle on correcting some of the doses and symptoms on the Freddd Protocol. I started the Freddd Protocol 2 months ago, and while I haven’t had the wild success or brightening as many people have, I did have some mood improvement, mild energy improvement, and induced potassium deficiencies (indicating new cell growth and working methylation). I’ll admit. I didn’t go about doing the protocol the best way. I probably started too fast, too high of methylfolate doses, and didn’t wait for mild deficiency symptoms to appear. I conflated and combined startup symptoms with folate deficiencies while also increasing doses to chase a big improvement/brightening. Now, I just want to undo as much as I can to get rid of some stubborn symptoms and restart to go again at more appropriate levels. I don’t think I can just increase folate since high doses haven’t helped. Main complaint currently: Very sore, achy, and tight muscles – painful even. Occurs mainly in arms, calves, and legs; and easy muscle burning (lactic acid feeling) from walking up stairs, changing lightbulb, scratching back, etc. Common concurring symptoms with muscle soreness: warm feeling in chest/abdomen, heart palpitations, tight muscles – mainly neck and Achilles These symptoms have been constant throughout doing the Freddd Protocol. This does not go away with potassium supplementation or with any increase in methylfolate (Extrafolate-S), even high doses. However, I think the soreness was greatly improved early on after a 1 time dose of 10mg of methylfolate (Metafolin). Other symptoms during Freddd Protocol: Joint pain in fingers, dry eyes, static shocks, flushing in face, malaise, irritability, runny nose, sore throat, dandruff, mouth sores, tongue and gum inflammation/discomfort, gas and bloating, foul smelling gas and stool Important Observations: --Have had induced potassium deficiency symptoms: headache, unbearable fatigue, malaise, very slight muscle cramping --First felt benefits taking 250mg LCF with noticeable mood improvement and mild energy improvement. Benefits faded after 3-4 days. No change when increasing to 500mg LCF. --Tried switching 500mg ALCar and had a huge jump in energy and mood for half a day. Definitely need ALCar over LCF. Slept like a rock during nap and that night. By the end of day, had intense migraine, terrible malaise, fatigue, worsened muscle aches and knots, tightness in calves, joint pain. Potassium and methylfolate had no improvement. --Tried 500mg ALCar again day after 1st time trying ALCar and only had negative symptoms. No benefits. --Tried liquid dosages of ALCar starting at 5mg and titrating. No benefits or negative symptoms. Only got headaches when titrating too quickly. --Taking 1000mg Niacin did not alleviate any symptoms, at anytime. Other Notes: --Been limited in eating vegetables to try and avoid folate. --Tried taking sublingual B2 FMN for several weeks to try and help decrease large folate needs. Noticed nothing from it. Frequently found myself urinating it out (neon yellow pee) despite breaking it up in smaller doses throughout the day. --Neon yellow urine taking B-Complex 2x/day, but not 1x/day. Critical Co-Factor Supplementation (Started for 4 weeks before FP): 1 B-Complex (Jigsaw) 250mcg Molybdenum 10,000 IU Vit. A 375mg Vit. E 20,000 IU Vit. D 1,000mg Vit. C 50mg Zinc 500mg Magnesium Multivitamin (pure encapsulations) 1g DHA 500mg Primrose Oil 53mg Lithium 25mg DHEA 200 mcg Selenium 2x/week 16.7mg Manganese 2x/week 3mg Boron – 2x/week 39mg Phosphatidylcholine 750mg TMG 2g Ribose 5g Creatine Deadlock Quartet Dosages: --Started at: 1mg mb12, 1mg folate, 300mcg ab12 --Peaked at: 4mg mb12, 50-70mg folate, 2.5mg ab12, 500mg LCF/ALCar --Tried taking a break from everything for a week after switching from 500mg LCF to 500mg ALCar. Felt better with headache and malaise going away and muscle aches lessening. After the large dose of ALCar, tried to take more syngergistically equal levels of the DQ. --Finished: 1mg mb12, 4mg folate, 1mg ab12, 5-20mg ALCar (titrated up by drops). --With trying my idea of synergistically more equal levels of the DQ, my muscle aches came back right away with heart palpitations, warm feeling in chest. I have been doing this for about 2 weeks and have stopped everything the past several days while I wrote this question up. My Theories: 1. Large Folate Deficiency - With my large DQ doses, I started too much healing and never squashed my low folate levels. I hope that switching to Extrafolate-S form of methylfolate from Metafolin was the reason high doses of folate did not help, even while trying it sublingually. Maybe if I took 40mg+ of Metafolin, my folate deficiency levels will go away. I think a large folate deficiency is the most likely case as I read a quote from Freddd that “even 100 mcg of absorbed mb12 can require 30mg of folate to prevent folate deficiency symptoms.” Taking B12 seems to cause my muscle aches and tightness to worsen. 2. Missing co-factor – My muscles ached even while other milder symptoms of folate deficiencies came and go, such as canker sores, runny nose, etc. 3. Methyl Trap – I am MTR/MTRR homozygous and maybe that muscle soreness symptoms of folate deficiency is due to too low of b12 rather than folate. 4. Carnitine Deficiency – Deficiency in carnitine can cause muscle aches. I seemed to consume the ALCar very quickly and subsequent doses of ALCar caused intense headaches and malaise. I read that the DQ we are most sensitive to indicates it is the DQ we are most deficient in. Also, titrating by drops did not cause any improvements, indicated needing more before any seeing any benefit. Titrating ALCar did not cause any anxiety or other emotional symptoms. What I’m going to do in the meantime is buy every form of methylfolate (Metafolin, Quatrefolic, Extrafolate-S, Magnafolate-C, and Deplin) and try taking large doses of it (40mg+) when a minimal dose of mb12 and ab12 to help get it into the cells, each brand for a couple days. I may try again using folate sublingually and maybe (though, dangerous) intranasally. Questions: --What would be a b12 dose appropriate that help carry folate into cells and solve folate deficiency while not starting new healing? --How do you know which B-vitamins (B1,2,3,6) to adjust and how? --Has anyone found other forms of folate (Quatrefolic, Extrafolate-S, Magnafolate-C, etc) to not work at all compared to Metafolin? I am very grateful to anyone who reads this and who can help. I can attach an excel sheet of my dosage and symptom diary on the Freddd Protocol if that helps. Thank you.