I have COMT and I just started introducing methylfolate after building b12's. I seem to be very sensitive to methyl's, getting very irritable feeling very unwell. So I am going very slow, I'm at 200mcg and holding. Do people usually adjust at some point to the methyls so that I can build. I'm in a catch 22 because I am getting really bad folate deficiency symptoms, but I really can't tolerate more methylfolate due to the methyls. Anyone been in this situation?