That sounds plausible. Do remember that the NAC will effectively shunt glutmate into making glutathione. The acetyl group I believe will allow it to be BBB at some level. So there may be a balancing act there. Trust me I know what high glutamate can do and it is vicious, but it often doesn't go awry by itself. I think NE is often involved in many cases of excititoxicity, etc. That is the central thesis of my doctor and he has certainly helped me. P.S. Just leave the magnesium glyicinate till bed time or really late in the day, when you don't need the cognition.