I am Homo CBSA360A and I went on a low thiol diet for months and although I didn't test sulfate levels I believe they dropped as I started feeling better. My general anxiety was gone for the most part but I definitely still have social anxiety and irratibility which would coincide on days with pain from injuries that were months old and still giving me grief. I started getting better because I believe the clean eating and supplementing reduced inflammation in my body. I recently figured out that it's the ammonia that is causing my anxiety, as well as a gaba/glutamate imbalance (supplements in gelatin casings increase anxiety within minutes). I realized when I take charcoal before bed I wake up the next day feeling like my wonderful extroverted self. Absolutely no anxiety, irratibility or brain fog. Now I need to figure how to keep ammonia levels down throughout the day because while I have lowered my protein intake for the cbs protocol I will ultimately go back to eating a lot of protein once my methyl cycle gets going. My Methylation Supplementation 2 weeks ago I started methyl b12 and methylfolate I'm doing two 1 mg mb12 jarrow lozenges twice a day and 1.6 mgs of solgar metafolin twice a day. I don't feel better or worst... havnt noticed any real startup reactions. (FYI I don't have cfs, just brain fog, irritability, anxiety and overall inflammation and generally feeling like crap). From my understanding, if cbs was not addressed, adding methyl donors would make me feel super for a couple days (honeymoon period) and then like crap. I've also read that all my methyl donors may just go down the cbs drain never making an impact. Which is it? Am I simply dosing too low to be feeling changes or getting detox reactions? Back to the ammonia Also, to combat my ammonia problem I have ordered l arginine and l ornithine... but they are amino acids and must be taken on an empty stomach. How can I mop up the ammonia that is produced because of the protein I eat during the day? Will loading up on ornithine or arginine first thing in the morning give me enough power to mop up ammonia throughout the day? I am trying to avoid yucca because of its estrogenic properties so if any one has any other methods to mop up ammonia please don't hesitate. If you have any specific probiotic strains that helped with lowering ammonia production or digestive enzymes that did the same I'd appreciate if you let me know.