I've been reading this forum for 8 months now and have learned so much from you all; am very grateful you are here. With mb12, mfolate, coq10, carnitine, ala, b2, b5, b6 I immediately begin urinating every 15-20 minutes, clear urine, unquenchable thirst and exhaustion. No 'wired-tired' feeling at all except at night when these supps cause twitchy insomnia. Does this look like hypokalemia to anyone? My potassium normally is 4.8 . Have high urea, although decreasing somewhat with less protein. I've read the threads about diabetes insipidus and wonder if I have that. My serum osmolality is 297 and my ratio of urine osmolality to serum osm. is 0.9. Without methyl donors, I still urinate a fair bit but nothing like with the methyls. Have stopped all methyl donors and afraid to try them again, so feel stuck and not sure what to do next. Have been off work due to fatigue for a year; 54 yrs; female. Have had 23andme, OATs, GI test, hormone profile, so could give more info, but thought this was enough for now. Any thoughts at all are most welcome.