Invest in ME Conference 12: First Class in Every Way
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Methyl-B12 + Methyl-folate = severe depression

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by outdamnspot, Nov 13, 2016.

  1. outdamnspot

    outdamnspot Senior Member

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    Has anyone else experienced anything like this?

    On Methyl-B12, I experienced some 'neurological brightening', i.e. more mental energy, enhanced colors, improved mood.

    On Methyl-B12 + B-Right, the effect was enhanced, but the crashes were worse -- I felt like something in the B-Complex was messing with my blood sugar, so I discontinued it for now.

    On Methyl-B12 (1-2mg) + 200mcg of Methylfolate (which I've been taking for the past 3 days), I experience the most crippling depression, anhedonia and feelings of withdrawal .. all I want to do is give up on everything and sleep.

    Additional symptoms are bloodshot eyes, skin peeling on my face, hands etc., increased balance problems, strange stools .. so is this possibly some kind of 'detox'?

    I am keeping up with my potassium needs.
     
  2. CCC

    CCC Senior Member

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    So, on just mB12 - you felt better (comparatively).

    On mB12 + anything with folate - you feel/felt terrible.

    Have you considered just taking the mB12 for a while? (+ potassium)

    On a non-CFS note, I find my skin is better and my eyes less bloodshot with B1 and some B2. But I don't have CFS.
    That said, be aware of Freddd's observation that B1 and B2 aren't good for him.
     
  3. outdamnspot

    outdamnspot Senior Member

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    The crashes on the B12 alone were too much and didn't seem to be easing up. Strangely, when I combine the B12 with the Methylfolate, the crashes aren't as debilitating -- and since I am trying to addressing my adrenal fatigue with methylation, I thought both supplements might be needed. Hence, why I was wondering if feeling worse might be 'detox'; I realize my throat is in fact very sore and raspy today, which is an unusual symptom for me.

    I'm waiting on my B12oil from Greg and may try his approach, but figured I would see what the B12 + folate did together first, since that was my doctor's initial suggestion.
     
  4. outdamnspot

    outdamnspot Senior Member

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    I tend to take the Methyl-folate close to my bedtime and actually find that it reduces subjective feelings of inflammation (i.e. I am more clearheaded after I take it).
     
  5. caledonia

    caledonia

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    Some people don't do well with folate. It eventually decreases serotonin. You can use SAMe instead.

    Go to my signature link and look at the link called Mental Illness and Methylation - William Walsh (at the bottom of the page).
     
    helen1 likes this.
  6. outdamnspot

    outdamnspot Senior Member

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    Well, I'm not sure if it's depression or 'detox', but I have been hit by signs of immune-activation -- like the sore throat, headaches, peeling skin, and my sinuses draining .. also, more spontaneous Candida clearance in my stools.

    When I first tried the B12, it floored me (I could barely stand), but the crashes seem to be more manageable now (2-3mg B12 and 200mcg Methylfolate, sublingual), so I will stick with it a bit longer.
     
  7. caledonia

    caledonia

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    @outdamnspot You could also try having a look at Ben Lynch's articles on methylfolate side effects and Freddd's info on paradoxical folate insufficiency.

    See the Ben Lynch section and the Freddd section in my signature link.
     
  8. flannery

    flannery

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    I just watched a video on methylation that was the best I've seen yet and the doctor says most definitely do not take Methyl folate if you are depressed. HIghly recommend watching this one.
     
    Sidney likes this.
  9. flannery

    flannery

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    Oops, I didn't realize that the video itself would post, if this is not allowed, please delete it.
     

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