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Methyl-acceptors?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by dannybex, Nov 13, 2014.

  1. dannybex

    dannybex Senior Member

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    I've read in several places that niacin is considered a 'methyl-acceptor' (or some say 'methyl-sponge'), but my doc said that B1, B2, and CoQ10 are also methyl-acceptors.


    Does anyone know if this is correct? The only mention I could find was from a book online:



    B1-B2-B3-CoQ10-METHYL-ACCEPTORS!.png
     
  2. PeterPositive

    PeterPositive Senior Member

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    I think it makes sense. There are many other discussions in this board talking about the appropriate balance of B1, B2 and B3 in a methylation protocol.

    High doses of those can make one's need for methylfolate and methyl-B12 "insatiable" as Freddd used to say. If you search a little bit you can find long threads about this issue.

    cheers
     
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  3. adreno

    adreno PR activist

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    On the other hand, B2 is also necessary for the methylation cycle.
     
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  4. PeterPositive

    PeterPositive Senior Member

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    Sure and so is B3, because of the role of NAD in the folate cyle, IIRC.
     
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  5. dannybex

    dannybex Senior Member

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    Can you explain this in more 'user-friendly' detail Peter? Thanks in advance…

    And the same for B2? I remember 'Dog Person' suggesting it's necessary, but can't remember the details…?

    Thanks Adreno.
     
  6. PeterPositive

    PeterPositive Senior Member

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    I am not a biochemist so my understanding is not very in depth.
    FAD (B2) and NAD (B3) are necessary for the MTHFR enzyme to do its work:

    http://en.wikipedia.org/wiki/Methylenetetrahydrofolate_reductase#Biochemistry
     
  7. ahmo

    ahmo Senior Member

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    Last edited: Nov 13, 2014
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  8. dannybex

    dannybex Senior Member

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    Thanks @ahmo -- I know Lynch has a lot of videos out there, so I appreciate your posting this one. I like the way he has been studying this in depth and has (at least most times) admitted if he's learned something new and makes changes accordingly (the infamous CBS mutation as one example).
     
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  9. Gondwanaland

    Gondwanaland Senior Member

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    Could you please post a link to that?
     
  10. dannybex

    dannybex Senior Member

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    From his "Seeking Health" Facebook page, confirmed via email -- see "Seeking Health's" reply…


    "...absolutely fine to take taurine - it supports magnesium absorption and electrolyte balance. The whole CBS upregulation and reducing sulfur long term is far from safe - or accurate. One needs sulfur - and this little bit of taurine is not going to harm - in fact, it's going to support."


    https://www.facebook.com/SeekingHealth/posts/831003603618985
     
  11. Gondwanaland

    Gondwanaland Senior Member

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    Ugh taurine knocks me out with sleepiness and brain fog. OTOH I can eat high sulfur foods w/o issues :confused:
    But I don't know my SNPs.
     
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  12. adreno

    adreno PR activist

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    Those effects have likely nothing to do with sulfur. Taurine functions as an inhibitory neurotransmitter in the CNS. The whole Yasko CBS tabernacle is bull.
     
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  13. Sidereal

    Sidereal Senior Member

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    Some people use it at night due to its sedating effect.
     
  14. Gondwanaland

    Gondwanaland Senior Member

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    I fall asleep quickly but have to wake up in the middle of the night to urinate since sulfur has a highly diuretic effect in me. I think I am so full of metals that sulfur supplements get detox going :eek:
     
  15. adreno

    adreno PR activist

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    Again, taurine inhibits aldosterone, which has a diuretic effect.
     
    Last edited: Nov 14, 2014
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  16. Gondwanaland

    Gondwanaland Senior Member

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    Thanks for the clarification :thumbsup:
     
    Last edited: Nov 14, 2014
  17. dannybex

    dannybex Senior Member

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    I thought taurine had a slight diuretic effect, and aldosterone helps retain fluids??? :)
     
  18. adreno

    adreno PR activist

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    That's what I said. Or meant to say. The inhibition of aldosterone has a diuretic effect.
     
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  19. dannybex

    dannybex Senior Member

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    Reviewing this thread again, it seems then like B2 anyway, is not a methyl-acceptor, like B3 -- it's a cofactor, at least at so-called 'normal' doses.

    I reduced, then basically stopped b2, with the exception of taking the RDA (1.7mgs), and my eyesight deteriorated big time during the last six weeks or so.
     
  20. Victronix

    Victronix Senior Member

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    Interesting, and good to know.
     

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