Hi, as perhaphs many of us I'm searching for treatment and I have been fascinated by the rituximab studies. I've been mostly bedbound the last year and consequently at least somehow desperate. In Germany it seems actually not possible to receive rituximab, even in case I sign documents that it will be offlabel and I accept all risks... But my doctors would give methodrexate a trial. So my questions: Does anybody has experience with it? Both good and bad experiences are welcome! @Jonathan Edwards : You think it is a sensible trail? You once wrote somewhere here that it has no clear cut mode and sience cannot draw conclusions if it works. But in the absence of rituximab, you think it is worth a trial? @deleder2k : you wrote that the bergen researches came to rtx through the experience from a chemo comb with methodrexate beeing part of. Was also rituximab part of this combo? In other words: can the improvement of cfs symptoms of the combo be tracked down most likely to methodrexate? http://www.biomedcentral.com/1471-2377/9/28 Here they reasoned in that direction. Maybe I missed some discussions here. Are there topics one can find only as logged in member? Any hint welcome!