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Methemoglobinemia

Discussion in 'General ME/CFS Discussion' started by nanonug, Mar 4, 2018.

  1. nanonug

    nanonug Senior Member

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    I just wanted to alert people to this hematological disease given its similarity, symptom-wise, to SEID. I haven't yet been tested for methemoglobinemia but plan to.

    Additional info on Wikipedia: https://en.wikipedia.org/wiki/Methemoglobinemia

    PS. I remember Ron Davis (if I'm not mistaken) suggesting in one video interview that blood from people with SEID have a "different color."
     
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  2. nanonug

    nanonug Senior Member

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    Good old Vitamin C may be a possible treatment for methemoglobinemia: "Role of ascorbic acid in the treatment of methemoglobinemia"

    Another interesting thing is that the enzyme Cytochrome b5 reductase, which converts methemoglobin to hemoglobin, is dependent on NADH. There is such a thing as acquired methemoglobinemia and I'm wondering if one couldn't end up with the condition in SEID even if methemoglobinemia is not congenital.
     
    Last edited: Mar 4, 2018
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  3. nanonug

    nanonug Senior Member

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    I've been doing some additional reading on methemoglobinemia and came across this info on CORE EMERGENCY MEDICINE website:

    Methemoglobinemia occurs when either:
    • There is an deficiency of the reducing enzyme (NADH MetHb reductase)
    • There is increased oxidative stress that cannot be handled by the body
    Acquired methemoglobinemia would therefore be a possibility in SEID.

    [​IMG]
     
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  4. nanonug

    nanonug Senior Member

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    From the study entitled "Erythrocyte Oxidative Damage in Chronic Fatigue Syndrome":

    Results
    There was evidence of oxidative damage in CFS with statistically significant increases in 2,3-DPG (p <0.05), metHb (p <0.005) and MDA (p <0.01). The CFS patients in this study also had significantly more stomatocytes in their blood than the normal subjects (p <0.005).

    Note that metHb is methemoglobin.
     
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  5. nanonug

    nanonug Senior Member

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    Link to document containg a color chart for the detection of the amount of methemoglobin in arterial blood: Methaemoglobin Color Chart.
     
  6. Learner1

    Learner1 Forum Support Assistant

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    What lab tests for it?
     
  7. CFS_for_19_years

    CFS_for_19_years Hoarder of biscuits

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    This would usually be performed in a large hospital laboratory with specialized equipment immediately after the blood was collected. Arterial blood is commonly used, but venous blood might be used.
     
  8. Learner1

    Learner1 Forum Support Assistant

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    So, is there a more accessible way of figuring out if one has this problem?
     

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