Powder amino acids might help, we're going to start monitoring a few patients over time to accurately determine correct ratios of supplements to see if we get a correlation in symptom improvement and to see what ratios of amino acids are optimal for the individual. This is just a treatment to help, we still believe the issue with glucose management is the important thread to pull.
OAT tests over the past 18 months or so show my glycolysis and Kreb's cycle pathways are really struggling. The Kreb's cycle pattern along with UAA tests convinced me that I am burning a lot of amino acids for energy.
A recent set of tests showed the worst ever results. This was no surprise as over the past 6 months or so I have almost ground to a halt - energy and neurotransmitter production barely enabling me to get by.
I've tried all the stuff to boost mitochondrial function, supplement B vitamins, carnitine etc that should be helping the energy pathways but to no avail.
After seeing the last results I decided to try amino acid supplementation. Yes it might be better to fix the glycolysis/Kreb cycle blocks but nothing I've tried works. Maybe providing more amino acid fuel might at least help me to function a bit better.
What amino acids?
I've had very bad experiences with whey protein, including highly purified derived peptides (fairly sure it is glutamates in it that I am sensitive to) so wanted to stay away from protein based preparations. Also had bad experiences with glutamate and glutamine so wasn't interested in total amino acid preparations.
I couldn't work out if some particularly amino acids would be better than others for energy burning purposes, so I ended up deciding to try an essential amino acid preparation. I figured this would boost the basic raw materials and my body could then decide which ones to send into the Kreb's cycle.
I did decide to add some acetyl-tyrosine I happened to have since my neurotransmitters are really struggling. Just roughly the same amount as the phenylalanine in the preparation.
I started with a fairly low dose (1/4 tsp - roughly 500 mg ) 3x daily on an empty stomach. I'm glad I started low - it was pretty electrifying at first - a lot of insomnia. However it was immediately obvious that it was helping.
The overstimulation has settled and I've moved up to 1/2 tsp 3x daily. I will increase this again and am hoping that like so many others things the benefits don't gradually peter out.
@ChrisArmstrong, short of a personalised strategy, do you have any thoughts about which amino acids might be best to boost energy production?