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Metabolic profiles in autism fit "purine-driven cell danger response" theory

Discussion in 'Other Health News and Research' started by natasa778, Dec 12, 2016.

  1. natasa778

    natasa778 Senior Member

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    Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism

     
    Last edited: Dec 12, 2016
    pibee, GreyOwl, J.G and 5 others like this.
  2. natasa778

    natasa778 Senior Member

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    Are there any studies or personal reports on B6-Mg++ supplementation in CFS/ME?
     
  3. lansbergen

    lansbergen Senior Member

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    @Valentijn Did you see any?
     
  4. roller

    roller wiggle jiggle

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    ... purine driven cell danger response ...

    with so much purine, tryptophan-failures and surinam, it seems worthwile to test spinal and urogenital fluid for all sort of protozoa (at least), no?

    have they tested the children for any?
     
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  5. taniaaust1

    taniaaust1 Senior Member

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    I did my own personal study on about 34? people here in the past and from that there was people here who were helped by B6 (though not many..I cant remember now it may of only been 2 or 3, half of us though here though are helped by one of the forms of B12 (from my results comparing lots of supplements we are all were on, I found B12 it be the most helpful supplement for ME)..

    There was a few here who were helped by B2 or B3. I found that around 75% of us with ME are helped by one of the Bs.

    I'm on the autism spectrum (aspergers). Ive had issues though with needing B12 and once the drs at hospital gave me a B3 injection for some reason unknown to me. I haven't found B6 in my case to be helpful, nor magnesium to be helpful at all.
     
    Last edited: Dec 12, 2016
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  6. Valentijn

    Valentijn Senior Member

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    There might be something. I think both were prescribed to me by a specialist at a Dutch fatigue clinic right before they went fully BPS. So he probably had some sort of basis for it.

    Personally, I find magnesium helpful, but only for avoiding muscle twitches and cramps.
     
  7. Solstice

    Solstice Senior Member

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    Almere?
     
  8. Valentijn

    Valentijn Senior Member

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    Lelystad.
     
  9. Solstice

    Solstice Senior Member

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    Ah right, I always get those two mixed up. Both in Flevoland province. But yeah, I heard they went full retard. Pity really.
     
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  10. ahmo

    ahmo Senior Member

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    Both are important for me. I'd taken B6 for years, before ME. When I finally found and switched to P5P version, there was a big shift, especially in my emotional climate. And these last weeks I've been in a very stressful situation, and have needed extra, large amounts of mg daily. I know I need more when I start getting cramps in hands or feet.
     
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  11. PennyIA

    PennyIA Senior Member

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    Very interesting. I didn't understand half of it... but I cannot tolerate any doses of B6 nor magnesium (though Epsom soaks work well from treating the cramping). And I have been diagnosed with gout post-MTHFR treatment where my purine levels keep flaring in uric acid issues.
     
  12. Sidereal

    Sidereal Senior Member

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    Naviaux specifically addressed the B6/Mg issue in one of his Q&A noting that ME/CFS patients can't tolerate the doses that babies with normal mitochondrial diseases tolerate easily.
     
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  13. pibee

    pibee

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    Very interesting. I thought I was the only person on the planet to feel worse from Magnesium even, because I talked to quite a few pwME who dont feel bad and have a deficiency (based on my RBC Mg i dont have it, it was even perfect).
    I also dont take absolutely any other supplements, because all make me feel worse, after 2-3 days.

     
    Sidereal likes this.

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