Julie Rehmeyer's 'Through the Shadowlands'
Writer Never Give Up talks about Julie Rehmeyer's new book "Through the Shadowlands: A Science Writer's Odyssey into an Illness Science Doesn't Understand" and shares an interview with Julie ...
Discuss the article on the Forums.

Metabolic profiles in autism fit "purine-driven cell danger response" theory

Discussion in 'Other Health News and Research' started by natasa778, Dec 12, 2016.

  1. natasa778

    natasa778 Senior Member

    Messages:
    1,773
    Likes:
    2,448
    Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism

     
    Last edited: Dec 12, 2016
    GreyOwl, J.G, trishrhymes and 4 others like this.
  2. natasa778

    natasa778 Senior Member

    Messages:
    1,773
    Likes:
    2,448
    Are there any studies or personal reports on B6-Mg++ supplementation in CFS/ME?
     
  3. lansbergen

    lansbergen Senior Member

    Messages:
    2,410
    Likes:
    2,397
    @Valentijn Did you see any?
     
  4. roller

    roller wiggle jiggle

    Messages:
    451
    Likes:
    212
    ... purine driven cell danger response ...

    with so much purine, tryptophan-failures and surinam, it seems worthwile to test spinal and urogenital fluid for all sort of protozoa (at least), no?

    have they tested the children for any?
     
    sue la-la likes this.
  5. taniaaust1

    taniaaust1

    Messages:
    11,870
    Likes:
    12,562
    Sth Australia
    I did my own personal study on about 34? people here in the past and from that there was people here who were helped by B6 (though not many..I cant remember now it may of only been 2 or 3, half of us though here though are helped by one of the forms of B12 (from my results comparing lots of supplements we are all were on, I found B12 it be the most helpful supplement for ME)..

    There was a few here who were helped by B2 or B3. I found that around 75% of us with ME are helped by one of the Bs.

    I'm on the autism spectrum (aspergers). Ive had issues though with needing B12 and once the drs at hospital gave me a B3 injection for some reason unknown to me. I haven't found B6 in my case to be helpful, nor magnesium to be helpful at all.
     
    Last edited: Dec 12, 2016
  6. Valentijn

    Valentijn The Diabolic Logic

    Messages:
    14,042
    Likes:
    43,567
    There might be something. I think both were prescribed to me by a specialist at a Dutch fatigue clinic right before they went fully BPS. So he probably had some sort of basis for it.

    Personally, I find magnesium helpful, but only for avoiding muscle twitches and cramps.
     
  7. Solstice

    Solstice Senior Member

    Messages:
    553
    Likes:
    1,796
    Almere?
     
  8. Valentijn

    Valentijn The Diabolic Logic

    Messages:
    14,042
    Likes:
    43,567
    Lelystad.
     
  9. Solstice

    Solstice Senior Member

    Messages:
    553
    Likes:
    1,796
    Ah right, I always get those two mixed up. Both in Flevoland province. But yeah, I heard they went full retard. Pity really.
     
    Valentijn likes this.
  10. ahmo

    ahmo Senior Member

    Messages:
    4,318
    Likes:
    6,424
    Northcoast NSW, Australia
    Both are important for me. I'd taken B6 for years, before ME. When I finally found and switched to P5P version, there was a big shift, especially in my emotional climate. And these last weeks I've been in a very stressful situation, and have needed extra, large amounts of mg daily. I know I need more when I start getting cramps in hands or feet.
     
    natasa778 likes this.
  11. PennyIA

    PennyIA Senior Member

    Messages:
    718
    Likes:
    1,660
    Iowa
    Very interesting. I didn't understand half of it... but I cannot tolerate any doses of B6 nor magnesium (though Epsom soaks work well from treating the cramping). And I have been diagnosed with gout post-MTHFR treatment where my purine levels keep flaring in uric acid issues.
     
  12. Sidereal

    Sidereal Senior Member

    Messages:
    3,067
    Likes:
    16,950
    Naviaux specifically addressed the B6/Mg issue in one of his Q&A noting that ME/CFS patients can't tolerate the doses that babies with normal mitochondrial diseases tolerate easily.
     
    merylg and natasa778 like this.

See more popular forum discussions.

Share This Page