To those who are considering using Metabolic Maintenance (MM) 10mg 5-MTHF Quatrefolic, take note: This did not give me any noticeable startup, even with a dose of 2x 10mg. 2x 800mcg Solgar Metafolin was far more effective (excitoxicity haven). In both instances I took supplements from the deadlock quartet. Not only was this disappointing from a financial perspective (MM isn't cheap.. 100 dollars per bottle), it also made me look outside methylation for a while. I was only able to come back to methylation because I still had 2 Solgar tablets left around. Back to Solgar and to methylation!