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Nitric oxide and its possible implication in ME/CFS (Part 1 of 2)
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Metabolic features of the cell danger response

Discussion in 'Other Health News and Research' started by natasa778, Jun 17, 2014.

  1. natasa778

    natasa778 Senior Member

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    open access article http://www.sciencedirect.com/science/article/pii/S1567724913002390
    BadBadBear, Sidereal, adreno and 3 others like this.
  2. natasa778

    natasa778 Senior Member

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    Super interesting and relevant article. Few more bits

    BadBadBear, Sidereal and melihtas like this.
  3. natasa778

    natasa778 Senior Member

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    Disorders corrected or improved by antipurinergic therapy.

    Disease Species Antipurinergic drug Reference
    Autism Mice Suramin Naviaux et al. (2013)
    Spinal cord injury Rats Brilliant Blue GPeng et al. (2009)
    Traumatic brain injury Rats and Mice MRS2179 Choo et al. (2013)
    Ischemic brain injury Rats Suramin Kharlamov et al. (2002)
    Glutamate excitotoxicity Rats Suramin Bezvenyuk et al. (2000)
    Epilepsy Mice A438079 Engel et al. (2012)
    Rheumatoid arthritis Rats Suramin Sahu et al. (2012))
    Chronic pain RatsP2X3-15h Cantin et al. (2012)
    Multiple sclerosis Mice Suramin Novales-Li (1996)
    Lupus erythematosis Mice Suramin Ballok and Sakic (2008)
    Restenosis after angioplasty Rabbits SuraminGray et al. (1999)
    Duchenne cardiomyopathy Mice Suramin de Oliveira Moreira et al. (2013)
    Heart failure Rats Apyrase Marina et al. (2013)
    Alcoholic liver disease/cirrhosis Rats SuraminHe et al. (2013))
    AsthmaGuinea Pigs Suramin Oguma et al. (2007)
    Emphysema Mice Suramin Cicko et al. (2010)
    Diabetic kidney disease Rats Suramin Korrapati et al. (2012)
    melihtas likes this.
  4. lansbergen

    lansbergen Senior Member

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    Good find natasa.

    They phrase it clear and simple.
  5. daisybell

    daisybell Senior Member

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    natasa778 likes this.
  6. natasa778

    natasa778 Senior Member

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    Interesting that effects of a single dose lasted for about 5 weeks. What is the average duration of rituximab effects?
  7. cigana

    cigana Senior Member

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    Absolutely fascinating!

    Does anyone know if it's possible to obtain sumarin, or if there are natural antipurinergic therapies?
  8. natasa778

    natasa778 Senior Member

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    looks like pyridoxine (vit B6) is an antagonist of (some?), but could not find much more than this

    Effect of P2 receptor blockade with pyridoxine on sympathetic response to exercise pressor reflex in humans

    btw does this type of 'autonomic adjustment seen with exercise' link to CFS/Julia Newton research?
    cigana likes this.
  9. cigana

    cigana Senior Member

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    Here is a paper that lists some natural antagonists of P2X:
    • emodin, an anthraquinone obtained from rhubarb
    • An herbal product used in Chinese medicine called ligustrazine
      (tetramethylpyrazine), an alkaloid derived from Ligusticum wallichii
    • bisflavonoids from the methanolic extract fractions of Rheedia logifolia
    EDIT: Pharmaceutical antagonists listed here and in here.
    Last edited: Jun 28, 2014
    natasa778 likes this.
  10. alex3619

    alex3619 Senior Member

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    I haven't read the articles yet, my brain is not functioning well enough just now, but the key thing to look for, as a first pass in thinking about this, is if there is any disturbance in purinergic metabolism. Elevated uric acid is a common finding in CFS and ME. Mine was so high I was actually put on gout medication once.
  11. natasa778

    natasa778 Senior Member

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    these are possibly relevant/indicative:

    http://www.ncbi.nlm.nih.gov/pubmed/22210239

    http://www.ncbi.nlm.nih.gov/pubmed/19647494
  12. natasa778

    natasa778 Senior Member

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    from 2011 InvestinME recap

  13. MeSci

    MeSci ME/CFS since 1995; activity level 6

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    Emodin may not be suitable - it can cause diarrhoea and vomiting. I had to throw away a resveratrol supplement as it also contained emodin and upset my stomach. It's a common 'contaminant' of resveratrol supplements as many of them are derived from Japanese knotweed, which also has a high emodin content.
  14. MeSci

    MeSci ME/CFS since 1995; activity level 6

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    Animal 'models' are very poor predictors of human responses. Having studied and worked on the subject of species differences and relevance of animal 'models', I ignore them.
    cigana likes this.

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