Discussion in 'Other Health News and Research' started by natasa778, Jun 17, 2014.
open access article http://www.sciencedirect.com/science/article/pii/S1567724913002390
Super interesting and relevant article. Few more bits
Disorders corrected or improved by antipurinergic therapy.
Disease Species Antipurinergic drug Reference
Autism Mice Suramin Naviaux et al. (2013)
Spinal cord injury Rats Brilliant Blue GPeng et al. (2009)
Traumatic brain injury Rats and Mice MRS2179 Choo et al. (2013)
Ischemic brain injury Rats Suramin Kharlamov et al. (2002)
Glutamate excitotoxicity Rats Suramin Bezvenyuk et al. (2000)
Epilepsy Mice A438079 Engel et al. (2012)
Rheumatoid arthritis Rats Suramin Sahu et al. (2012))
Chronic pain RatsP2X3-15h Cantin et al. (2012)
Multiple sclerosis Mice Suramin Novales-Li (1996)
Lupus erythematosis Mice Suramin Ballok and Sakic (2008)
Restenosis after angioplasty Rabbits SuraminGray et al. (1999)
Duchenne cardiomyopathy Mice Suramin de Oliveira Moreira et al. (2013)
Heart failure Rats Apyrase Marina et al. (2013)
Alcoholic liver disease/cirrhosis Rats SuraminHe et al. (2013))
AsthmaGuinea Pigs Suramin Oguma et al. (2007)
Emphysema Mice Suramin Cicko et al. (2010)
Diabetic kidney disease Rats Suramin Korrapati et al. (2012)
Good find natasa.
They phrase it clear and simple.
Interesting article but too much for my brain to process!
I found this article on suramin following a link.... http://www.medicalnewstoday.com/articles/278364.php
Interesting that effects of a single dose lasted for about 5 weeks. What is the average duration of rituximab effects?
Does anyone know if it's possible to obtain sumarin, or if there are natural antipurinergic therapies?
looks like pyridoxine (vit B6) is an antagonist of (some?), but could not find much more than this
Effect of P2 receptor blockade with pyridoxine on sympathetic response to exercise pressor reflex in humans
btw does this type of 'autonomic adjustment seen with exercise' link to CFS/Julia Newton research?
Here is a paper that lists some natural antagonists of P2X:
emodin, an anthraquinone obtained from rhubarb
An herbal product used in Chinese medicine called ligustrazine
(tetramethylpyrazine), an alkaloid derived from Ligusticum wallichii
bisflavonoids from the methanolic extract fractions of Rheedia logifolia
EDIT: Pharmaceutical antagonists listed here and in here.
I haven't read the articles yet, my brain is not functioning well enough just now, but the key thing to look for, as a first pass in thinking about this, is if there is any disturbance in purinergic metabolism. Elevated uric acid is a common finding in CFS and ME. Mine was so high I was actually put on gout medication once.
these are possibly relevant/indicative:
from 2011 InvestinME recap
Emodin may not be suitable - it can cause diarrhoea and vomiting. I had to throw away a resveratrol supplement as it also contained emodin and upset my stomach. It's a common 'contaminant' of resveratrol supplements as many of them are derived from Japanese knotweed, which also has a high emodin content.
Animal 'models' are very poor predictors of human responses. Having studied and worked on the subject of species differences and relevance of animal 'models', I ignore them.
I'm bumping this thread in light of the new findings of OMF.
tetramethylpyrazine looks interesting.
While you're interested in this you might have a look at my recently blog post concerning functional sympatholysis. It's not the best thing I every wrote, for reasons explained in the write up, but it does complete a link I've been looking for for a long time between different processes involved in exercise intolerance. I've also checked that it is virtually unknown among practicing M.D.s.
In view of the fact that (overactive?) purinergic signalling appears to be a key factor in the Cell Danger Response, would that imply that foods high in purines would exarcebate the problem? Should we avoid foods (such as sardines) that are high in purines? Many thanks for any advice.
If you were missing genes for tumour suppression(maybe viral suppression too) would you end up in a constant state of cell danger response
Good question. That makes me wonder if shutting off the cell danger response could have negative effects for some of us.
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