I started a mestonin trial, but it's not looking good at the onset. Presently I have air hunger issues similar to @Webdog, OI/NMH issues, bradycardia, palps, muscle weakness, afternoon low grade fevers, and I'm sure I don't need to say constant fatigue. I currently tolerate some activity (slow walking intensity) as long as I can get some hours of recliner rest during the day. Midodrine didn't help low BP, but did seem to help air hunger. I tapered off of it to try mestonin, and find air hunger is worse when I take mestonin, and my BP has dropped a bit lower. My diastolic is dropping into the 40's which feels awful. I started at a quarter tab mestonin 3x per day, and moving to a half tab made things worse, so I suspect I will wash out of my trial soon. Will probably go back to midodrine and experiment a bit more with a super low dose of yohimbe. Talked to my doc and may try LDN next. I didn't chase symptoms too much before, but I'm getting worse and weaker and am scared.