A bit late, but I promised to report about Mestinon Trial (@echobravo) My new GP takes M.E. seriously. Not only that, he allows me to trial Mestinon without going through a specialist which would be the normal route for this kind of off-label medication use. It works well for a subgroup of POTS patients and also PWME have reported benefits. https://www.healthrising.org/blog/2...nic-fatigue-vagus-nerve-stimulation-exercise/ Prescribed dosage varies a lot, from 10mg to 180 mg or even more. I will start low. So today: 5mg No noticeable effects so far. I will update this thread and report of benefits vs side effects as I keep increasing the dosage. I wanted to keep the poll options limited (simple). But let me know if you want me to add options.