I have been taking slow release mesalazine for a year since I was diagnosed with ulcerative colitis. At first it had no noticable effect on the ME/CFS (though I was very sick with both so I guess it was hard to distinguish at the time). But, now that my UC is 95% better, if I forget to take a dose, as I have four or five times now, then my "inflammation" -- that I associate with ME/CFS and which was present before the UC -- ramps up very noticably and I feel much worse for a day or two until the drug gets back to normal levels in my system. It's too big a difference for me to pass up this chance to figure out what might be going on. I still feel very sick with ME/CFS when I'm taking the drug as normal, but still, there is an undeniable and repeatable worsening if I forget to take the drug. My UC does not noticably get any worse. So is the mesalazine actually having some kind of positive effect on the ME/CFS? And if so, what might be the method of action? When I was being seen by KDM I had very high PGE2 and IL-8 (which I understand is driven by PGE2) and I know that one thing mesalazine does is inhitit COX-2 which drives PGE2 production. Is this why then, or perhaps something else is going on?