Today I saw my Immunologist/Allergist/Physician, who I have not seen since 2009. My Rheumatologist ran out of ideas & felt I should go back to see the Immuno. My Immuno's overall impression is that I have a Connective Tissue Disorder of some kind!!! (and that in 5 yrs time, we will be able to sequence my whole genome & find out what it is!!! ) He is pleased I am seeing the Neurogenetics & General Genetics Clinics through the public hospital He noted my insulin resistance/fatty liver/difficulty losing weight due inability to exercise much with fatigue & arthritis issues. He thought I may feel better on Diaformin XR (Diabex XR, Metformin HCl) so I am going to try it (500 mg one with dinner) if OK after 2-3 wks increasing to two a day with dinner. I have a HIDA nuclear medicine scan tomorrow http://www.mayoclinic.com/health/hida-scan/MY00320 so I will hold off starting any drugs til after that. It's a scan to monitor function of liver biliary tract & gall bladder function. This test was ordered by my GP who thinks I may have sluggish/sludgy gall bladder. My Immuno ordered these tests today: IgE RAST moulds x 4 Chromatin ANA/ENA/RF/dsDNA/ACE MSU & casts, CK IgGAM, IgG subclasses Amylase, Lipase EPG I/E serum, urine Serum B2M Tryptase Chromogranin A FBE, ESR, CRP ASOT, DNASE B B27 TBNK subsets (A hospital Rheumy I saw last week as an inpatient, said I had Fibromyalgia...with all the classic tender points. He also wrote up that I had Sjogren's Syndrome...regardless that my tests for SS are all negative. He prescribed me Nortryptiline 10 mg once/day and recommended that PACING helps a lot of FM patients ) I have tried Nortryptiline & Amytryptiline low dose before. Am willing to try again...after my HIDA scan. One drug at a time...sigh... My Immuno said YES it IS possible to have Sjogren's Syndrome but test negative. And YES it IS also possible to have Lupus but test negative for ANA.