I missed this forum somehow (and thus this thread)...hypoadrenism is one of my biggest ongoing problems. There's a lot of great info here! Did not know this information about low iron and cortisol...that's very interesting. Yet another piece of the puzzle for me thanks to Phoenix Rising Forums! So now I'm wondering if chronic anemia has been part of my adrenal problems all along. No doctor has ever mentioned this possible link between the two. Last September my ferritin level was a whopping 9, the all-time low . In January it was 13, despite an iron transfusion in October. After the iron transfusion it went briefly up to about 50, but then plummeted rapidly. So for the last month I've been taking about 50mg iron glycinate/day at the same time as 2000mg liposomal vitamin C, along with the methylB12 and adB12 I take for methylation. It took me a while to decide to do supplement oral iron, as I already take a bunch of supplements and iron is a PITA as you shouldn't mix it with food or other minerals if you are concerned about getting maximum absorption. I plan my daily schedule around taking iron right now. But I'll never do another transfusion again (expensive and not worth the trouble or expense, IMHO) , and eating liver can suppress the thyroid, so this is my only option. After only a month of this my ferritin went from below 13 to 22. It's still a work in progress but I expect to have normal ferritin level (over 50) by the time I go back in July. I may have it tested in May just to make sure I don't get too high. There is some evidence to suggest that there is increased inflammation with ferritin level over 50. Taking iron at the same time as vitamin C increases absorption. And apparently if you're B12 deficient your body can't hang onto whatever iron you give it, even if you give it a lot. Personally, I think chronic B12 deficiency was a big part of my problem. I also have female problems, but ferritin level after the transfusion dropped so rapidly and the level from taking oral supplements after fixing my B12 status has risen so quickly that my anemia can't possibly be all from the female thing. The female thing has been ongoing for years and while I've had lower ferritin and iron levels for a while, the very, very low levels are a relatively recent development (within the last couple of years). Apologies if the vitamin C and B12 things have been mentioned and/or covered thoroughly before in this thread or elsewhere. I haven't had time to read this whole adrenal forum or even this whole thread. Just thought I'd throw it out there as I didn't see them mentioned in the few posts I have read, and I consider them crucial.