If some cases of CFS are actually caused by mitochondrial failure, then I wonder how someone would do by megadosing literally every mitochondrial related supplement that is available. I realize this could be cost prohibitive for the long term, but it would be interesting to see what happened in the short term. Perhaps the could be mega dosed pre/post exersize or activity as well. The following supplements could be part of the megadosing experient. Creatine Monohydrate: 5 grams BID CoQ10 (or a lower dose of ubiquinol): 1000 mg BID D-Ribose: 7.5 mg BID Adb12: 4000 mcg BID (sublingual) NADH: 10-20 mg BID Transdermal Magnesium Cholride: 8 sprays BID Magnesium L-Threonate: 100 mg BID L-Carinitine (optionally NAC or LCF): 2 grams BID Pyrroloquinoline quinone (PQQ): 20 mg BID Also this assumes all critical EAA's, minerals, and vitamin intake is already accounted for. The following medications could also be used (optional): t3 slow release or regular cytomel (carefully titrating up to highest dose that dosen't cause hyperthyroid symptoms) Any thoughts on what to add to this list?