Last year I had a sleep study which ruined me for a week. I was diagnosed with alpha intrusion or alpha over delta. Alpha waves are the short bursty brainwaves of an active brain. In my case, they continued all night, so I do not ever get REM 3/4 sleep. Xyrem was great while my insurance covered it. Slept great and felt rested. Relieved the foggy, confused feeling I have most of the time. In place of the Xyrem, my PCP prescribed up to 150 trazadone and 100 tramodol at 7:30 pm, then up to 150 trazadone, 100 tamodol and Lunesta at bedtime. I vary the doses, but that combination gives me some sleep relief and I don't need that heave sedation now. I'm back to the CFS symptoms, but I am getting some sleep which is better than no sleep.