I'm going to tread very lightly here as I firmly believe that ME is a biomedical disease. You very likely cannot cure HIV, MS, or cancer with mediation alone and the same is very likely true of ME Also many people with ME will be unable to meditate given neurological symptoms. I am often in that place myself And of course many people with ME meditate for years without significant changes to their core symptoms This post in no way is meant to support the biosocial or central sensitization models of ME or take focus away from biomedical studies and interventions. -------------- I came across an interesting study today linking meditation to regulation of the anterior cingulate (AC) which in turn modulates both the peripheral sympathetic nervous system (SNS) and the central locus coeruleus (LC) norepinephrine systems. I'll leave further parsing of the neurological mechanisms of action to better informed posters. The reason this study was interesting to me is because many, if not most, of the recovery stories I've read include a form of mediation or purposeful relaxation practice (caveat being that many mediation / Gupta / ANS Rewire / DNRS recovery stories are likely misdiagnosis or exaggerations). I've also spoken with many recovered / vastly improved patients (in real life and over PMs on PR) who undoubtably had classic Ramsay ME and used some sort of mindfulness practice (including programs like DNRS and ANS Rewire) as a cornerstone of their protocol (along with biomedical treatments). Could it be coincidence? Of course, there are obviously no good double blind longitudinal studies here. And do other physiological benefits of mediation like stress reduction, lowered BP / HR, and lowered cortisol play a role? I'm sure they do. But I've been racking my brain to tie a link between mediation and elements of core ME neuroinflammation, and this study may be a clue. Or I may be grasping at straws, but I'd be curious to hear the thoughts of others.