I have just completed a blog post about what has helped me when I have been most disabled by this illness and in such poor a state that I felt I could not go on any longer. I have tried what must be over a hundred different interventions for this illness. So few have been of any use. In this blog I outline the ones that have not changed my life but have at least maintained my head above the water life. I focus principally on the Glutamate, NMDA and GABA systems and the severe impact these can have on symptoms. http://findanswerstome.blogspot.co.uk/2012/03/medical-intervention-for-someone-in.html I hope this may help some people. For the many of whom are drug sensitive always start with half or quarter tablets, or by breaking a capsule open and taking roughly half of the contents. I take LIV 52 tablets and SAM-e to help the liver metabolize these compounds without any undue hepatic effects.