Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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Meaningless Rickettsia results?

Discussion in 'Lyme Disease and Co-Infections' started by Gondwanaland, Apr 13, 2015.

  1. Gondwanaland

    Gondwanaland Senior Member

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    Just got my husband's Rickettsia results:

    RICKETSIA RICKETTSII IGG antibodies
    Indirect immunofluorescence (blood)
    <1:40 (negative= <1:64)

    RICKETSIA RICKETTSII IGM antibodies
    Indirect immunofluorescence (blood)
    <1:10 (negative= <1:64)

    I find it funny that there is a specific number above which one can be considered ill (>1:64)

    Any input on these results anyone?
     
  2. Jonathan Edwards

    Jonathan Edwards "Gibberish"

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    These are rather odd figures. They are dilutions and the figure given will be the highest dilution at which an immunfluorescent signal can be detected. What is odd is that dilutions go in doublings, so they are often
    1:10, 1:20, 1:40. 1:80, 1:160 or
    1:4, 1:8, 1:16, 1:32, 1:64

    So having results of 1:10 or 1:40 with a reference cut off of 1:64 does not make much sense.

    I cannot say how the reference cut off is arrived at but would expect it to indicate the level below which the great majority of normal controls are found or some statistically calculated level that best distinguishes known cases from controls. It would not be intended to be interpreted as 'ill or not' on its own I think - it would contribute to a physician's evaluation of the probability of infection.
     
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  3. Gondwanaland

    Gondwanaland Senior Member

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    @Jonathan Edwards thanks, now I have a starting point to discuss it with the dr.!
     
  4. Oredogg

    Oredogg

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    Oregon
    I'm with @Jonathan Edwards the reference range does not make sense with the patient result. The patient testing should be done in the same manner as the reference interval. I'd raise this issue to the lab, since you are paying for this test, and have them explain and/or repeat the test with appropriate controls. I am a pathologist and former lab director, so this is an area I have some experience with.
     
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  5. Gondwanaland

    Gondwanaland Senior Member

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    Thank you @Oredogg I will discuss this with the dr!
     

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