Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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ME1 Category of ME/CFS

Discussion in 'General ME/CFS Discussion' started by Strawberry, Jul 28, 2015.

  1. Strawberry

    Strawberry Senior Member

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    @Jonathan Edwards I read in this thread this morning: http://forums.phoenixrising.me/index.php?threads/do-mes-cause-cfs.31930/

    You stated somewhere that rituximab didn't work with those with ME1 with ANA speckled pattern? Is there something that does possibly work? Or at least, is it known why rituximab doesn't work for that group of people?

    For those not wanting to read his full introduction in that other thread, ME1 is this:

     
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  2. Jonathan Edwards

    Jonathan Edwards "Gibberish"

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    I am not sure that I said that rituximab did not work for such people - it has not been tried as far as I know. However, rituximab seems to have rather little impact on speckled ANA autoantibodies - we think that this may be because they are made by very long lived plasma cells. So if a form of ME is caused by such antibodies it may not respond well. Remember that these categories are suggestions rather than anything proven.
     
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  3. Strawberry

    Strawberry Senior Member

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    Is ANA (speckled pattern) really of any concern? I have no idea if it has anything to do with my health issues or not...
     
  4. Jonathan Edwards

    Jonathan Edwards "Gibberish"

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    Lots of people have speckled ANA antibodies without being unwell so al most certainly the antibodies are sometimes of no importance - just like for anti-thyroid antibodies or in fact rheumatoid factors.
     
  5. Strawberry

    Strawberry Senior Member

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    Thank you! Nice to hear, and I won't worry about unless it interferes with treatment.
     
  6. WillowJ

    WillowJ คภภเє ɠรค๓թєl

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    What are some more examples of diseases that might be caused by speckled ANA autoanitbodies or these plasma cells that make them? Do they have any treatment strategies? Is it something someone could study for ME1?

     
  7. Strawberry

    Strawberry Senior Member

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    Willow, this is what they know speckled pattern ls linked to:
    (stolen from here: https://labtestsonline.org/understanding/analytes/ana/tab/test/)

    I luckily (or not so lucky?) don't have connective tissue issues, but it leaves me in the dark why I have the markers. I'd love to see someone study the link, but what is the percentage of CFS with ANA? It might be a smaller and less important group, considering if I remember right Dr Edwards said in his theory that ME1 is no sudden onset, slow spiral, and usually not as severe as other forms. But that thread is quite the chore to filter through to verify that! :D
     
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