Not sure if this has been posted previously.... http://www.tandfonline.com/doi/full/10.1080/17513758.2012.704083 Can persistent Epstein–Barr virus infection induce chronic fatigue syndrome as a Pavlov reflex of the immune response? DOI: 10.1080/17513758.2012.704083 Elena Agliariab*, Adriano Barracd, Kristian Gervasi Vidale &Francesco Guerracf pages 740-762 Publishing models and article dates explained Received: 24 Nov 2011 Accepted: 13 Jun 2012 Version of record first published: 16 Jul 2012 Article Views: 664 Abstract Chronic fatigue syndrome is a protracted illness condition (lasting even years) appearing with strong flu symptoms and systemic defiances by the immune system. Here, by means of statistical mechanics techniques, we study the most widely accepted picture for its genesis, namely a persistent acute mononucleosis infection, and we show how such infection may drive the immune system towards an out-of-equilibrium metastable state displaying chronic activation of both humoral and cellular responses (a state of full inflammation without a direct ‘causes–effect’ reason). By exploiting a bridge with a neural scenario, we mirror killer lymphocytes TK and B cells to neurons and helper lymphocytes and to synapses, hence showing that the immune system may experience the Pavlov conditional reflex phenomenon: if the exposition to a stimulus (Epstein–Barr virus antigens) lasts for too long, strong internal correlations among B,TK and TH may develop ultimately resulting in a persistent activation even though the stimulus itself is removed. These outcomes are corroborated by several experimental findings.