Is this just my impression or it really is that ME has bigger gene/hereditary component than "other" autoimmune diseases? In my family we all have Hashimoto (mom,sister,myself and i'm quite certain my grandmom had too), as for ME, i have most pronounced, but based on all my moms descriptions of her fatigue - she has a very mild form of ME too (she never took 1 day off from work in 40 years of working so it really is mild) but she is brain foggy and once she is in house, she is very lazy to go even 200 meters by foot. i remember she was like this 20 yrs ago too when i was kid anyway, she def has ME. and, she has many bartonella symptoms so i think she has bart. my sister even mildest form but she also feels it (she has a bit of fibro too, and Sjogren antibodies so maybe could be not-ME fatigue) I had Lyme specific symptoms from very early, so there is possibility i have congenital Lyme and my sister has some specific symptoms, ... so maybe this is big trigger for my family's case ... but not sure what to believe anymore. ..when i look at other diseases like MS, ... there doesnt seem to be so many families as ME with more than 1 member having it?