They all work together as part of one's immune system. All three are associated with allergies, for example. I am afraid, however, that your question is too broad to have an easy answer. You may want to look at Table 1 on the following document to see if it rings any bells. In my opinion, the more symptoms you are able to match from different categories, the stronger the case would be to get tested for mast cell disorders: "Polycythemia From Mast Cell Activation Syndrome: Lessons Learned."