Does anyone have both? Did your endo start before the ME/CFS?. I know these two illnesses are thought to be related due to problems with the immune system, and ME/CFS often co exists with endo. I have had endo since I was 14 and developed ME/CFS at 18. I never realised that endo effected the immune system until I thoroughly researched it. I have found when my endo is really bad, so is the ME/CFS and I get massive pimple outbreaks (i'm in my 30's now). It all seems to go together, I really think the endo lead me to developing ME/CFS. I am waiting on an operation for the endo and really wonder how this is going to effect the ME/CFS Has anyone had the operation for endo and how did you go with it?.