It's all in the SNPs Interpretation Guide I sent you. You would start with the First Priority mutations. For you, that would be ACAT, and possibly a trial of folinic acid for SHMT, then CBS. You only need to treat CBS if it's expressed (causing problems). There are a couple of tests you can do along with signs and symptoms to see if CBS is expressed. Or you could do what I did, which was "bass ackwards" - I skipped over CBS and started adding methylcobalamin, and started having anxiety on an amount even as low as 1mcg (yes, that's microgram and not milligram). Then I had to go back and do CBS treatment. Then I was able to tolerate methylfolate at higher amounts. If I had bothered to do testing, I would have seen a high value on a urine sulfate strip beforehand and saved myself some suffering. That's why Amy Yasko developed this method after working with thousands of patients. So just start at the top of the document and work your way down, one SNP at a time (as it applies to you). Start with very low doses as described in Start Low and Go Slow. If you run into problems, see if you can find a description of how to debug it in Roadblocks to Successful Methylation Treatment. If not, come on here and start asking questions.