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Mast cells in human adipose tissue: link with morbid obesity, inflammatory status, and diabetes

Discussion in 'Mast Cell Disorders/Mastocytosis' started by nanonug, Nov 19, 2012.

  1. nanonug

    nanonug Senior Member

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    Virginia, USA
    1. J Clin Endocrinol Metab. 2012 Sep;97(9):E1677-85. doi: 10.1210/jc.2012-1532. Epub
    2012 Jun 28.

    Mast cells in human adipose tissue: link with morbid obesity, inflammatory
    status, and diabetes.

    Divoux A, Moutel S, Poitou C, Lacasa D, Veyrie N, Aissat A, Arock M, Guerre-Millo
    M, Clément K.

    Institut National de la Santé et de la Recherche Médicale Unité 872, Nutriomique,
    and Université Pierre et Marie Curie-Paris 6, Centre de Recherche des Cordeliers,
    Unité Mixte de Recherche (UMR) S872, F-75006 Paris, France.
    adeline.divoux@flhosp.org

    AIMS AND HYPOTHESIS: Mast cells are immune cells known for their role in several
    inflammatory and fibrotic diseases. Recent works in mice suggest that mast cells
    could be cellular actors involved in the pathophysiology of obesity, a disease
    characterized by white adipose tissue (WAT) and systemic inflammation. The aim of
    the study was to better characterize mast cells in WAT of obese with or without
    type 2 diabetes and lean subjects as well as to explore the relationship with WAT
    inflammation and fibrosis. METHODS: Subcutaneous and omental adipose tissue from
    six lean subjects, 10 obese nondiabetic, and 10 diabetic patients was analyzed by
    immunohistochemistry and real-time PCR for inflammatory and fibrosis markers.
    Cytokines secretion of mast cells isolated from WAT and cultured in different
    conditions was estimated by cytokine array kit. RESULTS: We found that mast cells
    are activated in human adipose tissue and localized preferentially in fibrosis
    depots, a local condition that stimulates their inflammatory state. Mast cells
    with tryptase(+) chymase(+) staining tended to be higher in obese omental adipose
    tissue. We found positive links between mast cell number and several
    characteristics of obese WAT including fibrosis, macrophage accumulation, and
    endothelial cell inflammation. Mast cell number and their inflammatory phenotype
    are associated with diabetes parameters. CONCLUSION AND INTERPRETATION: Mast
    cells are cellular actors of WAT inflammation and possibly fibrotic state found
    in obesity and diabetes. Whether mast cells could be involved in the
    pathophysiology of diabetes needs additional study as well as the positioning of
    these cells in driving pathological alterations of WAT in these chronic metabolic
    diseases.

    PMID: 22745246
  2. camas

    camas Senior Member

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    Oregon
    After reading this a few weeks ago, I decided to finally get serious about losing my 20 extra pounds. I assume that by losing some of my belly fat, that some mast cells might go with it. Four pounds down, 16 to go...
  3. nanonug

    nanonug Senior Member

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    Virginia, USA
    Yeap, same thinking here. 30 pounds to go, though... :)
    camas likes this.
  4. Sherlock

    Sherlock bicarb for exercise recovery and taming candida

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    US
    What is the average BMI or waist-to-height in CFS? Is it high?
  5. camas

    camas Senior Member

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    Oregon
    That's a good question. I wonder if this has ever been studied? I've been both under and overweight in my 25 years of being ill. I'm at my heaviest now at 53 (no big surprise) and am having to carefully count calories since I can't exercise this fat off.

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