The 12th Invest in ME Research Conference June, 2017, Part 2
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MAO A R297R rs6323 TT +/+ status causing histamine intolerance since starting meth protocol?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by chilove, Nov 7, 2013.

  1. chilove

    chilove

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    Hi guys,

    Awhile back I posted about my histamine intolerance becoming severe after starting methylation protocols (although I benefit from them in other ways).

    Do you know if this MAO A R297R rs6323 TT +/+ status is likely what's causing histamine intolerance?

    Thanks so much!

    Audrey
     
  2. heyitisjustin

    heyitisjustin Senior Member

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    MAOA is involved in breaking down histamine so to some degree yes.
     
  3. alicec

    alicec Senior Member

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    Australia
    That SNP doesn't do anything. See here and here for posts on MAO A SNPs.
     
    Valentijn likes this.
  4. Valentijn

    Valentijn Activity Level: 3

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    The function of the gene doesn't carry over to all (or even most) of the SNPs on it. The SNP quoted doesn't impact upon MAOA function.
     
  5. Critterina

    Critterina Senior Member

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    Arizona, USA
    Did you check your DAO status? Here is one article: http://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2011.02548.x/full
    It does state that the genetic background of HIT is unknown. I don't think it even mentions my homozygous SNP, which is rs2111902, risk allele is G.
     

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