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Manufacturing New Gut to Treat GI Diseases

Discussion in 'Other Health News and Research' started by Waverunner, Dec 4, 2013.

  1. Waverunner

    Waverunner Senior Member

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    While you could read about new hearts, new livers, new kidneys etc., the intestine was never mentioned. For people with IBD or cancer or other diseases, which affect the intestine, it can be a huge problem to lose parts due to damage and surgery.

    http://www.sciencedaily.com/releases/2013/12/131203112217.htm

    Dec. 3, 2013 — For those living with gastrointestinal disorders, such as ulcers or Crohn's disease, treatment often means quelling uncomfortable symptoms through medications or dietary changes. But what if one day treatment meant doing away with the old gut for a new gut free of inflamed or diseased tissues?

    That is where scientists at Brigham and Women's Hospital (BWH) and Massachusetts Institute of Technology (MIT) are hoping their new study findings will lead. In their work, the researchers were able to grow extensive numbers of intestinal stem cells, then coax them to develop into different types of mature intestinal cells.

    The study is published online in this month's Nature Methods.

    "Being able to produce a large inventory of intestinal stem cells could be incredibly useful for stem cell therapy, where the cells could be delivered to patients to treat diseases such as Crohn's disease and ulcerative colitis," said Jeffrey Karp, PhD, Division of Biomedical Engineering, BWH Department of Medicine, co-senior study author. "These cells could also be useful for pharmaceutical companies to screen and identify new drugs that could regulate diseases from inflammatory bowel disease, to diabetes, to obesity. However, to date there hasn't been a way to expand intestinal stem cell numbers."

    In the "crypts" of the human gut are immature adult stem cells that live alongside specialized cells called Paneth cells. The stem cells remain immature as long as they remain in contact with Paneth cells. But the researchers found that when Paneth cells are removed and replaced with two small molecules involved in cell signaling, these molecules could direct the stem cells to develop into pure populations of proliferating stem cells. By introducing other molecules to the mix, the pure cells could further develop into specialized mature intestinal cells.

    "This is an opportunity to generate a large number of relevant mature gastrointestinal cell types that was not possible before and enable high-throughput screening using these cell types," said Xiaolei Yin, PhD, Center for Regenerative Therapeutics, BWH Department of Medicine, lead study author.

    Moreover, the researchers note that their findings could be potentially applied for in vivo use of small molecule drugs to help regenerate cells to replace damaged gut tissue caused by disease.

    "This opens the door to doing all kinds of things, ranging from someday engineering a new gut for patients with intestinal diseases to doing drug screening for safety and efficacy," said Robert Langer, ScD, MIT, co-senior study author.
    Last edited: Dec 6, 2013
  2. Sparrowhawk

    Sparrowhawk Senior Member

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    West Coast USA
    This would be huge, thanks for posting.
    Waverunner likes this.
  3. Overstressed

    Overstressed Senior Member

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    Belgium
    I read some years ago that Dutch scientists(from Nijmegen) managed to produce new intestines. I'll see if I can find back that paper.

    I don't know what the difference is between this and their paper, though...

    Thanks for posting!

    Best wishes,
    OS.

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