Even though I've been going very low and slow, I've run into the dreaded "potassium deficiency with methylation startup" problem, and would like to hear about your experiences with this, and how you got through it. The symptoms are very similar to magnesium deficiency, and my potassium showed good on my Nutreval test, so I got mislead into thinking I needed more magnesium supplementation. This was the wrong thing to do. After having problems, I consulted with my doc and he got me straightened out. I shut down methylation with niacin, and I'm currently doing high potassium foods and avoiding magnesium supplements, and I'm feeling much better. My symptoms were heart palps, a stressed feeling, progressing into more and more anxiety, until I started having panic attacks waking me up during sleep, twitching feet waking me up during sleep, and a rash between my baby and ring finger. What I call magnesium deficiency symptoms are heart palps and twitchy feet waking me up during sleep. Who knows, maybe those have been potassium symptoms the whole time, or maybe a combination of magnesium and potassium deficiency. Anyway, once I get straightened out, I'm going to resume methylation. So that means going through another period of a high need for potassium. I'm interested in hearing how people got through this. Were you able to go low and slow enough to manage it via foods and/or low level balanced supplementation, as through a multivitamin or an electrolyte supplement? I'm leery of taking potassium-only supplements as there could be a danger of skewing your electrolytes the other way, as I did with magnesium supplementation. If you were successful, how long did it take you to get through this step? I've done a little research, and the potassium thing seems to be unique to ME/CFS patients. Yasko doesn't mention it, and Rich Vank wasn't aware of it until Freddd posted about it. A lot of people on here trying Freddd's protocol have posted about needing potassium supplementation, but I haven't seen this on Yasko's forum.