I've only been doing the simplified methylation protocol for 10 days but I wanted to share my experiences with magnesium in case it is helpful for anyone. I have magnesium injections as my magnesium was previously measured as low (in dr myhills tests). Before I started the SMP I had reduced the use of my injections to once every week or two as I didn't feel like my body needed them as much. Since starting the SMP my need for magnesium has appeared to increase a whole lot. I have had cramps and also throbbing type pain in my arms and legs which I originally thought might be detox but almost completely went away 5 mins after my magnesium injections. The pain was more significant than the cramping feeling to be honest. I sometimes need to use 2 injections (ie 500 mgs since each one contains 250 mgs magnesium) to get the best response. I have also felt stiffness in my neck melt away with the magnesium. I feel as if the negative symptoms improve a lot if I either take some magnesium or some folate - both can be limiting factors. I occasionally got a great response to magnesium prior to starting the SMP - like the stiffness easing a lot in my neck - but it was very hit and miss. I can only think that my folate deficiency (or b12?) was limiting how much it could help me. When I first started mag injections they were quite painful to administer- as I did more they became almost pain free - I attributed this to my body being less deficient- I'm not sure if there's any science in this ! Anyhow, 3 days into the SMP when I thought I'd try a mag injection, it was as painful to inject as the first time over a year ago. So it felt to me as if I'd depleted my magnesium. I'm now injecting once a day at least when I feel I need it. Just as an aside, I tried a 500mg potassium oral dose and didn't feel any improvement. It's magnesium not potassium that seems to matter to me! Is my body therefore using a lot more magnesium now I'm on the SMP? Why? Another question- if I get all this response to mag injections does it mean I'm not absorbing it properly from my diet? Or that I just need much bigger doses than I can get that way? Hope that this is helpful to someone experiencing crappy symptoms on the SMP- without the magnesium I would be in a bad way by now.