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Maes Review: Mechanisms Explaining Muscle Fatigue and Muscle Pain in Patients with ME

Discussion in 'Latest ME/CFS Research' started by Cheesus, Jan 25, 2017.

  1. Cheesus

    Cheesus Senior Member

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    Gerwyn, M. & Maes, M. Curr Rheumatol Rep (2017) 19: 1. doi:10.1007/s11926-017-0628-x

    Purpose of Review

    Here, we review potential causes of muscle dysfunction seen in many patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) such as the effects of oxidative and nitrosative stress (O&NS) and mitochondrial impairments together with reduced heat shock protein production and a range of metabolic abnormalities.

    Recent Findings
    Several studies published in the last few years have highlighted the existence of chronic O&NS, inflammation, impaired mitochondrial function and reduced heat shock protein production in many patients with ME/CFS. These studies have also highlighted the detrimental effects of chronically elevated O&NS on muscle functions such as reducing the time to muscle fatigue during exercise and impairing muscle contractility. Mechanisms have also been revealed by which chronic O&NS and or impaired heat shock production may impair muscle repair following exercise and indeed the adaptive responses in the striated muscle to acute and chronic increases in physical activity.

    Summary
    The presence of chronic O&NS, low-grade inflammation and impaired heat shock protein production may well explain the objective findings of increased muscle fatigue, impaired contractility and multiple dimensions of exercise intolerance in many patients with ME/CFS.

    http://link.springer.com/article/10.1007/s11926-017-0628-x (paywall)
     
    Jenny TipsforME, Sean, MeSci and 8 others like this.
  2. Jenny TipsforME

    Jenny TipsforME Senior Member

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    Is it only available behind a paywall? Do people agree this is useful evidence for stopGET stuff?
     
    trishrhymes likes this.
  3. RogerBlack

    RogerBlack Senior Member

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    This is a review article. It is only the two authors opinion and review of the literature - it has no evidence of its own, and draws no clearly obviously correct inferences that were new from published literature.

    Some aspects of the commentary seem plausible - I have not read it in detail as I haven't had enough coffee. Or have had too much.
     
    TiredSam likes this.
  4. trishrhymes

    trishrhymes Save PR. Sack the President of the Board.

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    Since it's a review study, it's gathering together information from other studies which we've presumably already seen. In that sense it's nothing new, though might be useful as a summary of evidence to support stopGET.

    Does anyone have access to the full paper?
     
    Lindberg likes this.
  5. AndyPR

    AndyPR RIP PR :'(

    MEMum and Jenny TipsforME like this.
  6. RogerBlack

    RogerBlack Senior Member

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    MEMum likes this.
  7. Snow Leopard

    Snow Leopard Hibernating

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    Um, Morris is a PwME, is somewhat well known in this community and left this forum under controversial circumstances years back (2010?). All I will say is I'm glad things have moved on since then!
     
  8. Jenny TipsforME

    Jenny TipsforME Senior Member

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    Yes this is what I mean. People aren't likely to read every paper but if you glance at this you might think "ah yes perhaps increasing exercise is the last thing these people need to be advised to do!"
     
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  9. RogerBlack

    RogerBlack Senior Member

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    Ah - interesting.
     
    MEMum likes this.

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