I am new to this Forum... glad to have found it. I have a 20 year history of ill health, and an "officical" diagnosis of CFS. I now know that the underlying problem is a combination of genetic blocks in the Folate/methylation and CBS cycle and this has left me with persistant infections of Lyme and Chlamydia Pneumonia and also serious Lead toxicity ( from renovating and old house.... I stripped off all the old paint using a hot-air gun ) Attempts over the past 7 years to treat the infections and chelate the Lead have just made me feel "poisoned" and all this has been exaccerbated since, 5 years ago I was diagnosed with Hemochromatosis ( a genetic disease which causes high Iron levels ) The treatment for this is to have regular removal of blood. Now I know that this helped the iron levels to come down, but because I have MTHFR C677T +/+, it made the Folate deficiency even worse. 5 years ago my MCV was 102. Following the de-ironing it came down the expected 5% to 97%, but has steadily risen since then and it is now 107. My red blood cells are 3.63 (3.8-5.00) and my Platelets are133 ( 140-440) I started taking Folapro, 800mcg and Hydroxy B12 2,000mcg and Adenosyl B12 2,000mcg in July last year. Didn't notice any reaction with the HB12, but did get very bad headaches with the AdB12 at first, and had to start with a lower dose. Adding in Methyl-B12 produces a huge detox reaction.... I can just about tolerate 2,000mcg.... but even with that I have a VERY strong metallic taste in my mouth. My MCV has not improved at all since I started this treatment. I don't see many people mentioning high MCV, but I think mine is pretty bad...... is it? I suspect that the doses I am on are not even touching the deficit What do I do?