Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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Lysine and Ammonia

Discussion in 'Alternative Therapies' started by dannybex, Feb 25, 2016.

  1. dannybex

    dannybex Senior Member

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  2. alicec

    alicec Senior Member

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    I don't have any specific information. However the first site is simply assuming that since lysine makes ornithine which in turn accepts and processes ammonia in the urea cycle, increasing lysine will necessarily increase ammonia uptake and processing.

    This is a very dubious assumption. In general, negative feed-back regulation is very common in biological systems and in particular, the urea cycle is very tightly regulated and unlikely to behave so simplistically.

    The other references put the proposition to the test in a whole person and show what actually happens - the opposite. I'd be more inclined to go with them.
     
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  3. xrayspex

    xrayspex Senior Member

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    I dont know but I suspect I have amonia problems and I feel like junk if take lysine, avoid like the plague
     
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  4. Sushi

    Sushi Senior Member Albuquerque

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    Hmm. I just got a lab test back showing elevated ammonia in serum--I'm interested!
     
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  5. dannybex

    dannybex Senior Member

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    I had elevated ammonia in a test from 2013, and have found connections to RLS which has been bugging me big time lately, so am trying to lower it. Of course RLS has other 'causes', but am trying to cover all the bases.

    Thanks for your replies everyone. :)
     
  6. ahmo

    ahmo Senior Member

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  7. dannybex

    dannybex Senior Member

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    Thanks @ahmo. I've been through that thread in the past and I think that's where I got the suggestion for lysine (along w/arginine and ornithine, which I do have in a supp). I'll have to check if I bookmarked any of that thread as it's now SO LONG -- too wiped to read it now.

    What did you end up using to lower ammonia?
     
  8. ahmo

    ahmo Senior Member

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    @dannybex I started w/ yucca, until I found that it's not great long term. Then switched to ornithine. Eventually I used a combo of ornithine, arginine, citrulline, lysine. I self-tested for which I needed, not all of them every day; lysine I used the least frequently. Then I followed the suggestions of that thread, and found I was able to quit all of those aminos, using only malic acid. I did this in footbath, as I have powder and it's really nasty tasting.
     
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  9. dannybex

    dannybex Senior Member

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    I know. I couldn't tolerate malic acid -- waaaaay too astringent/sour -- made me tighten up all over. But it is needed in the krebs cycle, so that may be how it helps? Interesting re the footbath mode.
     
  10. Violeta

    Violeta Senior Member

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    Last edited: Mar 24, 2016
  11. dannybex

    dannybex Senior Member

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    Jeez, my brain fog is terrible. Can't even remember that I was the one who started this thread just a month ago.

    sigh...
     
  12. Violeta

    Violeta Senior Member

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    Mainly I'm thinking that if they want to do a study on if lysine reduces ammonia, they should do it a different way.


    Well, a month and a half....:)
     
  13. dannybex

    dannybex Senior Member

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    Feb 25th - March 24 -- I'll call that a month. :)
     
  14. Violeta

    Violeta Senior Member

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    Oh sheesh, you're right!
     
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