I have been taking active methylfolate/b12 sublingual (1 in morning), optimal multivitamin, and homocystex plus (b12, tmg, riboflavin, methylfolate). It seems as though if I only take homocystex plus once or twice a week I will feel pretty good but it feels like it is too strong. I feel wired and alert like I drank a bunch of coffee (i hate coffee). I like feeling alert but I think the TMG is just too much stimulation for me to handle. I think I do better when I take 34 mg of activated riboflavin instead of the homocystex plus. Problem is, i feel under stimulated with just the riboflavin. I have also tried taking 30 mg of P5p 3x a day and zinc picolinate – 30mg twice a day but still feel pretty tired (this is without the homocystex plus). Do you think I should try higher doses of riboflavin or maybe try a lower strength form or TMG? I feel like I am right at the tipping point between under/over methylation and I’m having lots of trouble finding the right ratio of nutrients. I also have had chronic lyme for the past 8 years which seems to be a neverending and sometimes hopeless battle.