Note: this thread is split off from the thread: CFS is a metabolic condition! which is here. A Lack of Correlation between the Incidence of Lyme Disease and Deaths due to Alzheimer's Disease. O'Day DH1, Catalano A2. Author information Abstract Reports that Lyme disease (LD) causes Alzheimer's disease (AD) have appeared in academic journals and online. If the biological agent Borrelia burgdorferi that causes LD also causes AD, then areas with the highest levels of LD should have significantly higher numbers of deaths due to AD compared to low LD areas. Here we show there is no statistically significant correlation between the incidence of LD and deaths due to AD in the US. Furthermore, the 13 states with the highest deaths due to AD were statistically different (p < 0.0001) from those with high LD incidence.