New era for ME/CFS research as top cytokine study attracts media headlines
The immune systems of patients who have recently developed ME/CFS look markedly different from those who have been ill for much longer, according to a major new study from Drs. Ian Lipkin and Mady Hornig at Columbia University. This shift in immune function hadn’t been seen before.
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Lyme and Post Exertional Malaise

Discussion in 'Lyme Disease and Co-Infections' started by Ronan, Aug 10, 2012.

  1. Ronan

    Ronan Senior Member

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    Hi,

    I have been sick for over 10 years now am have also been under the impression that it was ME. I have now just tested positive for Bartonella and my ME doctor says this is the probable root cause of all my problems. I am going to start treatment now for Lyme. I am cunfused about one thing though. I have always had big problems with post exertional malaise but i thought this was not a symptom of Lyme? Is this the case or is this also a Lyme symptom?

    Thanks!
     
  2. Ema

    Ema Senior Member

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    Midwest USA
  3. Ronan

    Ronan Senior Member

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    Interesting Ema. Thanks. I was tested for Bartonella and Borrellia but not Babesia and from that thread it seems Babesia cause PEM and is often a coinfection with Lyme.
     
  4. richvank

    richvank Senior Member

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    Hi, Ronan.

    I wouldn't rule out other coinfections beside Babesiosis as causes for PEM. Actually, my current view is that Lyme disease can produce ME/CFS in those who are genetically susceptible, whether or not there are coinfections. Borrelia and at least three of the coinfections have been found to produce oxidative stress, which places a demand on glutathione. Borrelia depletes cysteine and glutathione in its host. Any factor that contributes to sufficiently depleting glutathione can contribute to producing ME/CFS, in my hypothesis, and if you have ME/CFS, you will have PEM/PEF.

    Best regards,

    Rich
     
  5. Ronan

    Ronan Senior Member

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    I'll have to ask my doc about it on my next visit and see if i should be tested for any other coinfections. I have been on GcMAF for a year and a half and he claims to be getting good results treating Lyme after patients have first got their Negalase levels into normal range before treating the Lyme.

    Thanks!
     

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