Weeks ago I entered in a hell, paranoia, panic attacks etc due excess of methyl supplements. THIS IS THE WORST THING I HAD IN MY ENTIRE LIFE. I was almost going to commit some madness... you know... I'm better now, used niacin last week, paranoia and panic attacks gone... but mild depression and anxiety still remaining from excess of methyl groups floating around. I hadn't anxiety neither mild depression before these uses. The big problem is: after 4 days of niacin use (100mg/day) I started to pee a lot, very thirst and I was smelling like soap (probably due ketones). This is pre diabetes symptoms. I stopped to use niacin but I developed a pain in the right side of my left rib, probably in the pancreas? I know, you'll say "ahh I use 500mg niacin with no problems". Nobody is equal! I AWAYS felt huge effects even with 25mg niacin. Diabetes runs in my family, so probably I have the genes!! I need to lower my methylation, BUT I CAN'T USE NIACIN AGAIN. Seriously. I can use hydrob12, folic acid (i haven't MTHFR mutations). I just don't know if these things lower my methylation. Seriously, I need help.