I've had air hunger for years, even before developing CFS. I have a history of asthma but albuterol, steroid anti-inflammatory inhalers, oral steroids, antacids, meditation, work up with cardiologist and pulmonogist did not help. With the onset of CFS I was also diagnosed with POTS, but treatment with Midodrine did not help the air hunger. I did not experience air hunger during the time I was taking sustained-release T3 (to resolve feeling cold). The air hunger for the most part resolved, and when I stopped the T3 (it was causing Plummer's nails at the dose that worked) it recurred. This was consistent with the work of a chiropractor, Dr. Lowe, that being functionally hypothyroid causes air hunger. Recent lab work shows a very low VEGF <30. I have read that low VEGF causes impaired oxygen diffusion resulting in air hunger, so I'm thinking that this low VEGF is the cause of my air hunger, and perhaps the liothyronine (T3) was helping with oxygenation. The only thing I can find that causes low VEGF is mold biotoxins. Anyone else have low VEGF? Is there any way to increase VEGF besides going through Shoemaker's Mold Protocol with VIP nasal spray?