Hi everyone I have been worse this year, and especially the past few months. I was finally able to get an appointment with my primary care doc. She tested me for a bunch of stuff, and found TSH was low at 2. Retested after 3 weeks, same result. I have never had thyroid issues (that showed up on tests). Am doing some crash-course reading, but am exhausted and brain foggy and reading gives me worse PEM, so I would be grateful for any tips. From what I have read so far, I am thinking to request the following tests, and, after them, start on LDN and see how that goes. (I have some LDN, but had been waiting, ironically, until I FELT BETTER before trying it for general ME/CFS sx.) Does this seem like a good plan? Tests: TSI TrAb maybe anti-TPO, relates to peroxide and methylation cortisol, maybe other adrenal sex hormones Other info: I have been doing a methylation protocol for a couple of years, but never tried LDN or l-carnitine. My methylation protocol only includes 1mcg (not mg) of b12 because I cannot tolerate more. My grandmother was hyperthyroid. I am guessing maybe the methylation has uncovered pre-existing tendencies towards hyperthyroidism... or maybe tweaked my peroxides in a weird way? Maybe that is why I cannot tolerate b12? I am 49 and still menstruating. @caledonia, do you have any insight on the b12 /peroxide / thyroid connection? I am so brain fuzzy today, but I think there may be something there.