The power and pitfalls of omics part 2: epigenomics, transcriptomics and ME/CFS
Simon McGrath concludes his blog about the remarkable Prof George Davey Smith's smart ideas for understanding diseases, which may soon be applied to ME/CFS.
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Low Neutrophils

Discussion in 'Immunological' started by Francelle, Feb 1, 2011.

  1. Francelle

    Francelle Senior Member

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    Victoria, Australia
    I'm just wondering if Neutropaenia/Neutropenia (low Neutrophils) is a common finding in M.E./CFS?

    If so, anyone have any theories on this?

    I have tried doing an archive search but so many irrelevant (to the topic) posts have come up I don't know where to locate any pertinent information.
     
  2. globalpilot

    globalpilot Senior Member

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    Ontario
    Hello,I'm not sure if it is a common finding or not, but it is an issue I've struggled with. Rich V explains it as a folate and/or B12 deficiency due to blocks in the methionine synthase enzyme. I was also reading today that the thyroid hormone modulates DNA transcription which creates RNA from DNA. So I wonder if a thyroid deficiency could result in neutropenia too. Interestingly enough, a woman on the cfsfmexperimental list did get her WBC up with thyroid medication.
     
  3. Glynis Steele

    Glynis Steele Senior Member

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    Newcastle upon Tyne UK
  4. LaurelW

    LaurelW Senior Member

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    Utah
    I've been wondering the same thing since I've had low neutrophils starting years before I got CFS. I also am hypothyroid but take hormone. I asked my doctor about it, and she said some people with CFS have neutropenia, but a lot don't.
     
  5. FunkOdyssey

    FunkOdyssey Senior Member

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    Count me among the people with CFS with low WBC caused by low neutrophils. I'm XMRV positive. I also have a borderline low platelet count and elevated mean platelet volume (MPV), if you're interested in other hematological findings.
     
  6. rlc

    rlc Senior Member

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  7. upnorth

    upnorth

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    Canada
    I'm one of those with frequent mild to mod. neutropenia. My CFS specialist speculates that may be due to chronic viral infection.
     
  8. FunkOdyssey

    FunkOdyssey Senior Member

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    Thanks for the suggestion and the link to that site! Really cool stuff. I haven't been tested specifically for either, however in the last few weeks I've begun high doses of methylcobalamin, adenosylcobalamin, methylfolate, and folinic acid, so I will definitely be interested to see whether there are any positive changes in my next blood test.
     
  9. rlc

    rlc Senior Member

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