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Low Levels of Vitamin A Cause Lowered ATP in Mitoichondria

Discussion in 'Other Health News and Research' started by liverock, Mar 26, 2010.

  1. liverock

    liverock Senior Member

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    Scientists Identify Vitamin A Role in Energy Production

    March 2010

    Vitamin A may play a critical role in the production of energy in our cells, says an international team of researchers who claim to have solved the question of why vitamin A deficiency causes so many diseases.

    According to findings published in the FASEB Journal, vitamin A (retinol) may play a role in the synthesis of ATP in mitochondria—the power plant of the cells—and when vitamin A is deficient the production of energy is reduced by 30%.

    Researchers led by Ulrich Hammerling from the Institute for Cancer Research, New York, found that when vitamin A supplies are adequate, the preferred energy sources are glycolysis and pyruvate production. On the other hand, when the vitamin is scarce the body turns to fat reserves, preparing the organism to win energy from fat oxidation.

    However, when cells are deprived of retinol, the synthesis of ATP decreases as does respiration. But such declines were reversed when retinol levels were restored, and no conversion to other retinoids was observed, showing the effect was related purely to retinol.

    "Bioenergetics is fundamental to all cells," wrote the researchers. "In view of this tenet, it is puzzling why metabolic regulation by the pathway described in this report depends on retinol that vertebrates cannot synthesize de novo (anew).

    "In limiting vitamin A to nutritional sources, there must be an evolutionary advantage of such import as to override the physiological needs for vitamin A in vision and retinoic acid-dependent transcription.

    "The answer may lie in the scenario that finite amounts of vitamin A are subject to depletion during periods of severe starvation when an organism is forced to conserve energy. Our observation that in the absence of vitamin A energy generation by respiration adapts downwards appears relevant in this context," added the researchers.

    Data from vitamin A-deficient mice has previously indicated that triglycerides accumulate in the liver and may signify a switch to fat for energy generation, said the researchers, in order to offset the limited use of glycolysis and pyruvate production.

    "It is also predictable that chronic deviations of vitamin A transport will lead to metabolic disease," Hammerling and his co-workers added.

    FASEB Journal 24(2):627-626, 2010


    Time to get out the cod liver oil again?:rolleyes:
     
    rippe and adreno like this.
  2. liverock

    liverock Senior Member

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  3. spindrift

    spindrift Plays With Voodoo Dollies

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    I am thrilled, I prefer carrots to cod liver oil. :Retro smile:
     
  4. rippe

    rippe

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    I depleted Retinol Levels by taking 1 000 000 IU of Hormone D over the course of one year resulting in low energy because of low copper/ceruloplasmin. CLO helped to reverse that.

     
  5. JPV

    JPV ɹǝqɯǝɯ ɹoıuǝs

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    How much CLO did you take per day and how long before you saw any positive results?
     
  6. rippe

    rippe

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    I'm still working on that. I took one tablespoon first but it was too much and I got really tired at afternoon. Now I take one teaspoon and I'm feeling slightly better every day. I feel like something happens with iron and copper metabolism and I have increased my intake of meat, liver and blood sausage to get more iron and copper. I feel like I need it now more than before. But I take a lot of K2 / Mk-7 and Taurine to handle the much calcium I recently got from that much D. I became sleepless and muscle cramping and hardening and it took me a while to find out that it came from too much calcium (D) and resulted in low ceruloplasmin due to low retinol from high D - according to Morley Robbins. I hope he is right in that, but my body response to CLO feels like something right is happening, but also many things that have been suppressed in the liver now happen very fast and heavily so I become very tired from CLO. I still could not find out why exactly retinol is so important with certain synthetsis, but maybe somebody knows more. I have this feeling that retinol is somehow underestimated because it is so essential and unspoken. I think there might be more to it. And I believe we usually don't eat enough organ meats, maybe?
    I don't want to spread wrong information and everybody should try to confirm this but I've read in an german kind of lexicon that the livers stellate cells capacity to store Vitamin A ist inexhaustible. I have to find out if its true. Because if it is the whole Vitamin A toxicity would be indeed another scare tactic. I don't know.

    https://en.wikipedia.org/wiki/Hepatic_stellate_cell
     
  7. rippe

    rippe

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    This are the sources quotations, which the article references about the storage capacity of retinol ester. But I don't know if they exist in english?
    1. Biesalski H. K., Köhrle J., Schümann K. (2002) Vitamine, Spurenelemente und Mineralstoffe. Prävention und Therapie mit Mikronährstoffen. Georg Thieme Verlag, Stuttgart
    2. Biesalski H. K., Fürst P., Kasper H. et al. (2004) Ernährungsmedizin. Nach dem Curriculum Ernährungsmedizin der Bundesärztekammer. 3. Auflage. Georg Thieme Verlag, Stuttgart
     

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