Thnx cfs since 1998, I do take probiotics all the time but it hasnt made any difference, or at least it didnt prevent it from happening. It might be worth me trying a higher dose though to see if that helps. Strange that the LDN has had that effect on me tho...maybe it will just be a case of my body getting used to it. Glad the probiotics helped you. Just out of interest which brand do you take, and what dose?